1)
Gunaratne AW et al. Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood. Cochrane Database Syst Rev. 2015 Jul 22;2015(7):CD010085.
Best KP et al. Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials. Am J Clin Nutr. 2016 Jan;103(1):128-43.
Garcia-Larsen V et al. Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis. PLoS Med. 2018 Feb 28;15(2):e1002507
2)
Middleton P et al. Omega-3 fatty acid addition during pregnancy. Cochrane Database of Systematic Reviews 2018;11:CD003402.
3)
Dies ist ein offiziell zugelassener «Health Claim» gemäss Lebensmittelgesetzgebung für die Augenentwicklung.
Campoy C et al. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. Br J Nutr. 2012 Jun;107 Suppl 2:S85-106.
4)
Dies ist ein offiziell zugelassener «Health Claim» gemäss Lebensmittelgesetzgebung für die Hirnentwicklung
Nevins JEH et al. Omega-3 Fatty Acid Dietary Supplements Consumed During Pregnancy and Lactation and Child Neurodevelopment: A Systematic Review. J Nutr. 2021 Nov 2;151(11):3483-3494.
Carlson SE, Colombo J. DHA and Cognitive Development. J Nutr. 2021 Nov 2;151(11):3265-3266.
5)
Jia Y et al. A dose-response meta-analysis of the association between the maternal omega-3 long-chain polyunsaturated fatty acids supplement and risk of asthma/wheeze in offspring. BMC Pediatr. 2022 Jul 16;22(1):422.
Bisgaard H et al. Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring. N Engl J Med. 2016 Dec 29;375(26):2530-9.
6)
Carracedo M et al. The resolution of inflammation through omega-3 fatty acids in atherosclerosis, intimal hyperplasia, and vascular calcification. Semin Immunopathol. 2019 Nov;41(6):757-766.
Auch die durch 2g EPA+DHA erreichbare Blutdrucksenkung wirkt sich natürlich positiv auf die Gefässgesundheit aus.
7)
Bork CS et al. Intake of marine and plant-derived n-3 fatty acids and development of atherosclerotic cardiovascular disease in the Danish Diet, Cancer and Health cohort. Eur J Nutr. 2023 Apr;62(3):1389-1401.
Siscovick DS et al. Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory From the American Heart Association. Circulation. 2017 Apr 11;135(15):e867-e884.
Auch die durch 2g EPA+DHA erreichbare Blutdrucksenkung wirkt sich natürlich positiv auf die Arteriosklerose aus.
8)
GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet. 1999; 354: 447-455
Abdelhamid AS et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2020 Feb 29;3(3):CD003177.
Bernasconi AA et al. Effect of Omega-3 Dosage on Cardiovascular Outcomes: An Updated Meta-Analysis and Meta-Regression of Interventional Trials. Mayo Clin Proc. 2021 Feb;96(2):304-313.
Elagizi A et al. An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health. Nutrients. 2021 Jan 12;13(1):204.
Hu Y et al. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants. J Am Heart Assoc. 2019 Oct;8(19):e013543.
9)
Zhang X. Omega‐3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose‐Response Meta‐Analysis of Randomized Controlled Trials. Journal of the American Heart Association. 2022;11:e025071
Offizieller Lebensmittelrechtlich erlaubter «Health Claim» bei 3g: DHA und EPA fördern einen normalen Blutdruck. Die positive Wirkung wird bei einer täglichen Gesamteinnahme von 3 g DHA und EPA erzielt.
10)
Hahn J et al. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ. 2022 Jan 26;376:e066452.
Ajabnoor SM et al. L. Long-term effects of increasing omega-3, omega-6 and total polyunsaturated fats on inflammatory bowel disease and markers of inflammation: a systematic review and meta-analysis of randomized controlled trials. Eur J Nutr. 2021 Aug;60(5):2293-2316.
Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017 Oct 15;45(5):1105-1115.
11)
Abdelhamid AS et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2020 Feb 29;3(3):CD003177.
Karalis DG et al. A Review of Clinical Practice Guidelines for the Management of Hypertriglyceridemia: A Focus on High Dose Omega-3 Fatty Acids. Adv Ther. 2017;34(2):300–323.
Offizieller Lebensmittelrechtlich erlaubter «Health Claim» bei 2g: DHA und EPA tragen zur Aufrechterhaltung eines normalen Triglyceridspiegels im Blut bei.
11b)
Deng W et al. Effect of omega-3 polyunsaturated fatty acids supplementation for patients with osteoarthritis: a meta-analysis. J Orthop Surg Res. 2023 May 24;18(1):381.
12)
Senftleber NK et al. Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. Nutrients. 2017 Jan 6;9(1). pii: E42.
Galarraga B. et al. Cod liver oil (n-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis. Rheumatology (Oxf., Engl.) 2008;47:665–669
13)
Bloch MH, Qawasmi A. Omega-3 Fatty Acid Supplementation for the Treatment of Children with Attention-Deficit/Hyperactivity Disorder Symptomatology: Systematic Review and Meta-Analysis, J Am Acad Child Adolesc Psychiatry. 2011 Oct; 50(10): 991–1000.
Gillies D et al. Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev. 2023 Apr 14;4(4):CD007986.
14)
Burckhardt M et al. Omega-3 fatty acids for the treatment of dementia. Cochrane Database Syst Rev. 2016 Apr 11;4(4):CD009002.
Huang Y et al. Associations of fish oil supplementation with incident dementia: Evidence from the UK Biobank cohort study. Front Neurosci. 2022 Sep 7;16:910977.
He Y et al. Circulating polyunsaturated fatty acids, fish oil supplementation, and risk of incident dementia: a prospective cohort study of 440,750 participants. Geroscience. 2023 Apr 12. Epub ahead of print. PMID: 37046127.
15)
Appleton KM et al. Omega-3 fatty acids for depression in adults. Cochrane Database Syst Rev. 2021 Nov 24;11(11):CD004692.
Sublette ME et al. Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. J Clin Psychiatry. 2011 Dec;72(12):1577-84.
Patan MJ et al. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials. Am J Clin Nutr. 2021 Sep 1;114(3):914-924.
Kiecolt-Glaser JK et al. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011 Nov;25(8):1725-34.
Patan MJ et al. Differential Effects of DHA- and EPA-Rich Oils on Sleep in Healthy Young Adults: A Randomized Controlled Trial. Nutrients. 2021 Jan 16;13(1):248.
16)
Lewis MD. Concussions, Traumatic Brain Injury, and the Innovative Use of Omega-3s. J Am Coll Nutr. 2016 Jul;35(5):469-75.
17)
Baker EJ et al. Metabolism and functional effects of plant-derived omega-3 fatty acids in humans. Prog Lipid Res. 2016 Oct;64:30-56.
Brenna JT et al, ISSFAL. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):85-91.
Gerster H. Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? Int J Vitam Nutr Res. 1998;68(3):159-73.
